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KMID : 0363020080380010083
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Journal of Korean Academy of Periodontology
2008 Volume.38 No. 1 p.83 ~ p.89
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Histomorphometric evaluation of bone healing with natural calcium carbonate-derived bone substitutes in rat calvarial defect
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Lee Chung-Ho
Jang Je-Hee
Lee Jae-Mok
Suh Jo-Young
Park Jin-Woo
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Abstract
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Purpose : This study investigated the osteoconductivity of natural calcium carbonate-derived bone substitutes, hen eggshell (ES), and compared with those of commercial bone substitutes.
Materials & Methods : Osseous defects created in the rat calvaria were filled with particulated ES(ES-1), ES with
calcium-deficient hydroxyapatite surface layer (ES-2), Biocoral(Inoteb, France), and Bio-Oss(Geistlich Pharma, Wolhusen, Switzerland). After 4 and 8 weeks of healing, histomorphometic analysis was performed to evaluate the amount of newly formed mineralized bone area (NB%).
Results : Histologic and histomorphometric analysis showed new bone formation and direct bony contact with the grafted materials in all groups. At 4 weeks, Biocoral group showed greater NB% compared to Bio-Oss and ES-1 groups (P<0.05). At 8 weeks, Biocoral and ES-2 groups showed significantly greater NB% compared to Bio-Oss group (P<0.05).
Conclusion : These results indicate that natural calcium carbonate-derived bone substitutes with microporous calciumdeficient hydroxyapatite surface layer may be an effective materials treating osseous defects. (J Korean Acad Periodontol 2008;38:83-90)
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KEYWORD
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bone substitute, calcium carbonate, osteoconductivity, histomorphometry
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